• In vitro skin integrity measurement

  • In vitro epidermis screening test

  • In vitro percutaneous absorption

Our team of experts have many years experience in the field of in vitro percutaneous absorption and the development of regulatory guidelines in this area. We offer the following services:

In Vitro Percutaneous Absorption (IVP) studies

  • Human dermal absorption assessment
  • Recognised alternative method (OECD 428)
  • Emulsions, Suspensions, Creams, Powders, Granules, Gels etc.
  • Radiochemical formulation preparation and analysis
  • Cold analytical techniques, including HPLC and GC
  • ICP-Optical Emission Spectroscopy (ICP-OES)
  • Additional analytical services available with partner laboratories

In Vitro Epidermis Screening Test (INVEST)

  • High throughput, cost-effective, fast delivery screen for product selection and formulation optimisation
  • Improved therapeutic efficacy of pharmaceuticals
  • Safer formulation development of agrochemicals
  • In vitro absorption through pig skin over 24 hours
  • 14C – analysis, HPLC or ICP-OES analysis
  • Summary reporting

Specialist diffusion cells

DTL has a range of custom-made glass diffusion cells that have been designed for dermal absorption studies with complex products. This includes filter trapping devices for mass balance recovery of volatile chemicals, large cells for the application of mixtures containing insoluble particulate actives or formulations containing metals, and mini-diffusion cells for studying the transdermal delivery of biologics or nano-formulations of drugs. Read more.

Consultancy services

We offer a consultancy service in the area of dermal absorption, including preparation of bridging cases, design and interpretation of percutaneous absorption studies for submission to various Regulatory authorities, including EFSA and SCCS in the European Union and EPA/FDA in the USA. We can provide advice on all aspects of percutaneous absorption including study review and guideline interpretation.