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Available on the TiV website as “open access” http://dx.doi.org/10.1016/j.tiv.2014.09.012
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Available on the TiV website as “open access” http://dx.doi.org/10.1016/j.tiv.2016.10.004
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Jon R. Heylings, Diane J. Davies, Timothy J. McCarthy and M. Catherine Correa
Skin that has a compromised stratum corneum is likely to provide a less effective barrier to topically-applied chemicals when compared with normal skin. For example, skin that is impaired due to irritation, sensitisation or more chronic skin disease, such as psoriasis, is likely to be a less effective barrier to the entry of chemicals into the systemic circulation via the dermal route (Goon et al., 2004; Kim et al., 2006; Stamatas et al., 2011). The measurement of dermal absorption of chemicals for consumer products intended for application to the skin is an important part of risk assessment (OECD, 2004; SCCS, 2010). However, the in vitro models that assess the dermal penetration of topically applied products utilise intact skin. Since there is no standardised model for evaluating skin penetration in compromised skin barrier conditions, the use of additional safety factors is arbitrary. The purposeof this investigation was to explore whether the tape stripping procedure used to assess the distribution of chemicals in the skin could be adapted, in vitro, to mimic conditions where there is damage to the stratum corneum barrier.Request a copy